TJHMS, Volume 8 Issue 3(July - Sept.) 2025
Review Articles
INTEGRATING STRESS MANAGEMENT IN TREATMENT OF CHRONIC DISEASE: A COMPREHENSIVE REVIEW OF HOMOEOPATHIC INTERVENTIONS
Dr. Tejaswinee Arun Mhaisale, Dr. Priya R Sheth
Background: Chronic diseases such as cardiovascular disorders, diabetes, autoimmune diseases, and chronic pain impose a significant global health burden. Increasing evidence highlights the critical role of stress as a modifiable risk factor influencing disease progression through dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, increased oxidative stress, and neuroimmune dysfunction. Effective stress management interventions have the potential to mitigate these effects and improve clinical outcomes. Objective: This comprehensive review aims to critically evaluate the role of psychological, physiological, and complementary stress management interventions, including homeopathy, in the prevention and management of chronic diseases. Methods: A systematic search was conducted across multiple databases, including PubMed, Scopus, Web of Science, Cochrane Library, and Embase, following the PRISMA 2020 guidelines. Data on intervention types, outcomes, and effectiveness were extracted. A qualitative synthesis was performed. Results: This study involving 105 studies found that psychological interventions like mindfulness-based stress reduction and cognitive-behavioral therapy improved emotional regulation, reduced cortisol levels, and enhanced treatment adherence. Physiological interventions like yoga and structured physical activity reduced autonomic dysregulation and systemic inflammation. Complementary medicine showed potential in modulating neuroimmune responses and enhancing systemic homeostasis. The majority of studies focused on cardiovascular disease, diabetes, and chronic pain. Despite strong evidence, heterogeneity in study designs and variability in outcome measures remains a challenge in standardizing treatment guidelines. Conclusion: This review highlights the therapeutic potential of stress management interventions in treatment chronic disease. Evidence suggests that integrative approaches encompassing psychological, physiological, and complementary modalities significantly improve disease outcomes by modulating neuroendocrine and immune functions. Future studies should focus on personalized, multidisciplinary, and technology-driven interventions to enhance chronic disease management and improve global health outcomes.
